Halperin S A, Eggleston P A, Beasley P, Suratt P, Hendley J O, Gröschel D H, Gwaltney J M
Am Rev Respir Dis. 1985 Nov;132(5):976-80. doi: 10.1164/arrd.1985.132.5.976.
To determine the incidence of wheezing in adult asthmatics with rhinovirus infection, we exposed 21 asthmatic volunteers to 1 of 2 rhinovirus serotypes. Symptoms, spirometry, and histamine inhalation challenge were assessed prior to, daily during, and 3 wk after the rhinovirus infection. Four volunteers had fiberoptic bronchoscopy performed on the fourth study day. Nineteen volunteers became infected with rhinovirus; 17 of 19 had typical coryzal symptoms. Volunteers did not have significant changes in spirometry or histamine sensitivity during rhinovirus infection when taken as a group or when categorized by severity of asthma or severity of the clinical illness. A subgroup of 4 volunteers was identified that had a 10% or greater decrease in FEV1 and a parallel increase in histamine sensitivity during rhinovirus infection; these 4 volunteers were not otherwise distinguishable from the group as a whole. Rhinovirus was recovered from bronchoscopy specimens of 1 of the 4 infected volunteers bronchoscoped. Thus, exacerbations of wheezing occurred in the minority of experimental rhinovirus infections in adult asthmatics, suggesting that other viral pathogens may play a more important role in precipitating asthma attacks.
为了确定感染鼻病毒的成年哮喘患者中喘息的发生率，我们让21名哮喘志愿者接触两种鼻病毒血清型中的一种。在鼻病毒感染前、感染期间每日以及感染后3周评估症状、肺功能测定和组胺吸入激发试验。在研究的第四天，对4名志愿者进行了纤维支气管镜检查。19名志愿者感染了鼻病毒；其中17名出现典型的鼻卡他症状。从整体来看，或者按照哮喘严重程度或临床疾病严重程度分类来看，志愿者在鼻病毒感染期间肺功能测定或组胺敏感性均无显著变化。有一个4名志愿者的亚组，在鼻病毒感染期间FEV1下降了10%或更多，同时组胺敏感性相应增加；这4名志愿者与整个群体在其他方面并无差异。在接受支气管镜检查的4名感染志愿者中，有1名的支气管镜标本中检测到了鼻病毒。因此，在成年哮喘患者的实验性鼻病毒感染中，少数会出现喘息加重，这表明其他病毒病原体可能在引发哮喘发作中起更重要的作用。
