肝支持系统：活性炭血液灌流对模型肝排泄性阴离子的低清除率。

Liver support systems: the low clearance of model hepatic excretory anions by charcoal hemoperfusion.

作者信息

Hew J T, Hart F E, Willson R A

出版信息

Gastroenterology. 1978 Apr;74(4):661-3.

Abstract

The removal of cholephilic anions (unconjugated bilirubin, bromosulfophthalein, and indocyanine green) by charcoal hemoperfusion was assessed in normal dogs. None of these model excretory compounds was effectively removed by the charcoal columns. In vitro studies suggested that poor removal of the anions was related to albumin binding in that, when the anions were in molecular solution, their extraction by the charcoal column was high; however, when albumin was added, their extraction was negligible. Therefore, if the removal from plasma of strongly bound toxins is important in the treatment of acute hepatitic failure, additional support devices may have to be encompassed into the ultimately hepatic support system.

摘要

在正常犬中评估了通过活性炭血液灌流去除亲胆阴离子（未结合胆红素、溴磺酞钠和吲哚菁绿）的情况。这些模型排泄化合物中没有一种能被活性炭柱有效去除。体外研究表明，阴离子去除效果不佳与白蛋白结合有关，即当阴离子处于分子溶液中时，它们被活性炭柱提取的效率很高；然而，加入白蛋白后，它们的提取量可忽略不计。因此，如果从血浆中去除强结合毒素对急性肝衰竭的治疗很重要，那么最终的肝脏支持系统可能必须包含额外的支持装置。