Horák J, Horký J, Rábl M
Digestion. 1980;20(1):22-30. doi: 10.1159/000198410.
The effects of 8-hour haemoperfusion through an activated charcoal column on fulminant hepatic failure were assessed in 10 dogs. The survival in the perfused animals was significantly prolonged and the onset of liver encephalopathy was markedly delayed compared to the controls. Significant decrease in plasma bilirubin and total plasma phenols was found in the perfused group. No other laboratory changes due to heemoperfusion were found. The charcoal column retained its adsorptive capability throughout the experiment as judged from phenol clearance values. In spite of current scepticism regarding its clinical use, further trials with haemoperfusion in acute liver failure seem to be warranted.
通过活性炭柱进行8小时血液灌流对暴发性肝衰竭的影响在10只犬身上进行了评估。与对照组相比，接受灌流的动物存活时间显著延长，肝性脑病的发作明显延迟。灌流组血浆胆红素和血浆总酚显著降低。未发现血液灌流引起的其他实验室变化。根据酚清除率值判断，整个实验过程中活性炭柱保持了其吸附能力。尽管目前对其临床应用存在怀疑，但似乎仍有必要对急性肝衰竭进行血液灌流的进一步试验。
