Tuff L P, Racine R J, Mishra R K
Brain Res. 1983 Oct 24;277(1):91-8. doi: 10.1016/0006-8993(83)90910-1.
Receptor binding estimates of the number of GABA and associated benzodiazepine (Bz) receptors were made in several brain regions following kindling. While the number of GABA receptors, as measured by both [3H]GABA and [3H]muscimol binding, was unaltered by kindling, Bz receptors were significantly increased in kindled amygdala and hippocampus. As the Bz receptor apparently functions to enhance GABA transmission, this finding suggests a possible mechanism for the kindling-induced enhancement of inhibition observed in previous evoked potential experiments.
在点燃后，对几个脑区中GABA受体和相关苯二氮䓬（Bz）受体的数量进行了受体结合评估。通过[³H]GABA和[³H]蝇蕈醇结合测量的GABA受体数量，并未因点燃而改变，但在点燃的杏仁核和海马体中，Bz受体显著增加。由于Bz受体显然起到增强GABA传递的作用，这一发现提示了一种可能的机制，可解释在先前的诱发电位实验中观察到的点燃诱导的抑制增强现象。
