温度对化学感受器纤维对化学试剂反应的影响。

Effects of temperature on the response of chemoreceptor fibers to chemical agents.

作者信息

Ito H, Eyzaguirre C

出版信息

Brain Res. 1983 Nov 21;279(1-2):286-90. doi: 10.1016/0006-8993(83)90194-4.

Abstract

The effects of stimulating (NaCN, ACh, eserine and haloperidol) and depressant (zero [Ca2+]o, mecamylamine and dopamine) agents of carotid body chemoreceptors were tested at different temperatures. Temperature was varied between 29 and 39 degrees C and Arrhenius plots of the sensory discharge frequency against the reciprocal of absolute temperature were constructed before and during application of the chemicals. NaCN, ACh and zero [Ca2+]o did not change the apparent activation energy (mu) whereas eserine, haloperidol and probably mecamylamine depressed mu. Dopamine probably increased mu. Thus, there were no uniform effects of temperature on the action of different chemosensory stimulants or depressants, suggesting that these agents act on different steps of a chain reaction.

摘要

在不同温度下测试了颈动脉体化学感受器的刺激剂（氰化钠、乙酰胆碱、毒扁豆碱和氟哌啶醇）和抑制剂（零[Ca2+]o、美加明和多巴胺）的作用。温度在29至39摄氏度之间变化，在施加化学物质之前和期间构建了感觉放电频率相对于绝对温度倒数的阿伦尼乌斯图。氰化钠、乙酰胆碱和零[Ca2+]o没有改变表观活化能（μ），而毒扁豆碱、氟哌啶醇以及可能的美加明降低了μ。多巴胺可能增加了μ。因此，温度对不同化学感觉刺激剂或抑制剂的作用没有统一的影响，这表明这些药物作用于连锁反应的不同步骤。