Heilmann L, Kurz E
Geburtshilfe Frauenheilkd. 1978 Feb;38(2):134-40.
Based on five cases of intrauterine death associated with preeclamptic toxemia, a possible relationship between the antihypertensive treatment with Catapres and the fatal outcome of the fetus is discussed. Catapres is known to decrease cardiac output and, in addition, diminishes the utero-placental circulation. For effective prevention of hemodynamic failure in such cases, it is advisable to use Catapres only in combination with adequate intravenous infusion therapy. Further investigations concerning this possible relationship should be done to determine sufficiently whether or not Catapres can be used without risk as a hypertensive drug in late gestosis.
基于5例与先兆子痫毒血症相关的宫内死亡病例,探讨了可乐定降压治疗与胎儿致命结局之间的可能关系。已知可乐定可降低心输出量,此外还会减少子宫胎盘循环。为有效预防此类病例中的血流动力学衰竭,建议仅在联合充分的静脉输液治疗时使用可乐定。应针对这种可能的关系进行进一步调查,以充分确定可乐定作为晚期妊娠中毒症的降压药物使用时是否毫无风险。