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阻断钠钾交换泵会导致细胞内钠含量降低吗?

Can blocking the Na/K exchange pump lead to a reduction in intracellular sodium?

作者信息

Cohen I S

出版信息

Experientia. 1983 Nov 15;39(11):1280-2. doi: 10.1007/BF01990370.

Abstract

It has been assumed that a rise in intracellular sodium should follow inhibition of the Na/K exchange pump. However, under certain conditions a reduction in intracellular sodium following pump blockage is possible. Many results postulating 'stimulation' of the Na/K exchange pump by low doses of the cardiac glycosides can be explained in this manner.

摘要

一直以来人们认为,抑制钠钾交换泵会导致细胞内钠离子浓度升高。然而,在某些情况下,泵被阻断后细胞内钠离子浓度有可能降低。许多关于低剂量强心苷“刺激”钠钾交换泵的研究结果都可以用这种方式来解释。

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