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阻断钠钾交换泵会导致细胞内钠含量降低吗？

Can blocking the Na/K exchange pump lead to a reduction in intracellular sodium?

作者信息

Cohen I S

出版信息

Experientia. 1983 Nov 15;39(11):1280-2. doi: 10.1007/BF01990370.

DOI:10.1007/BF01990370
PMID:6315475
Abstract

It has been assumed that a rise in intracellular sodium should follow inhibition of the Na/K exchange pump. However, under certain conditions a reduction in intracellular sodium following pump blockage is possible. Many results postulating 'stimulation' of the Na/K exchange pump by low doses of the cardiac glycosides can be explained in this manner.

摘要

一直以来人们认为，抑制钠钾交换泵会导致细胞内钠离子浓度升高。然而，在某些情况下，泵被阻断后细胞内钠离子浓度有可能降低。许多关于低剂量强心苷“刺激”钠钾交换泵的研究结果都可以用这种方式来解释。

相似文献

1
Can blocking the Na/K exchange pump lead to a reduction in intracellular sodium?阻断钠钾交换泵会导致细胞内钠含量降低吗？
Experientia. 1983 Nov 15;39(11):1280-2. doi: 10.1007/BF01990370.
2
Effects of digitalis on cell biochemistry: sodium pump inhibition.洋地黄对细胞生物化学的影响：钠泵抑制
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Cellular mechanism of action of cardiac glycosides.强心苷的细胞作用机制。
J Am Coll Cardiol. 1985 May;5(5 Suppl A):10A-15A. doi: 10.1016/s0735-1097(85)80458-7.
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The current concept for the cardiac glycoside receptor.当前关于强心苷受体的概念。
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Inhibition of the sodium pump in guinea-pig ventricular muscle by dihydro-ouabain: effects of external potassium and sodium.双氢哇巴因对豚鼠心室肌钠泵的抑制作用：细胞外钾和钠的影响
J Physiol. 1983 Jun;339:643-62. doi: 10.1113/jphysiol.1983.sp014740.
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Contribution of the Na+/K+-pump to the membrane potential.
Experientia. 1987 Dec 1;43(11-12):1135-40. doi: 10.1007/BF01945511.
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[Stimulation and inhibition of the sodium pump by cardiac glycosides].[强心苷对钠泵的刺激与抑制作用]
Bull Mem Acad R Med Belg. 1980;135(2):174-92.
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Electrophysiology of the sodium-potassium-ATPase in cardiac cells.心肌细胞中钠钾ATP酶的电生理学
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The electrogenic sodium pump in guinea-pig ventricular muscle: inhibition of pump current by cardiac glycosides.豚鼠心室肌中的生电钠泵：强心苷对泵电流的抑制作用。
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Effects of sodium-potassium pump inhibition and low sodium on membrane potential in cultured embryonic chick heart cells.钠钾泵抑制和低钠对培养的鸡胚心脏细胞膜电位的影响。
J Physiol. 1987 Jun;387:549-66. doi: 10.1113/jphysiol.1987.sp016588.

引用本文的文献

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Effects of stimulation and diphenylhydantoin on the intracellular sodium activity in Purkinje fibres of sheep heart.刺激和苯妥英对绵羊心脏浦肯野纤维细胞内钠活性的影响。
J Physiol. 1985 May;362:331-48. doi: 10.1113/jphysiol.1985.sp015681.
2
Relation between Na+-K+ pump, Na+ activity and force in strophanthidin inotropy in sheep cardiac Purkinje fibres.洋地黄毒苷增强绵羊心脏浦肯野纤维收缩力作用中钠钾泵、钠活性与力之间的关系。
J Physiol. 1988 Oct;404:275-99. doi: 10.1113/jphysiol.1988.sp017290.
3
Dissociation between force and intracellular sodium activity with strophanthidin in isolated sheep Purkinje fibres.

本文引用的文献

1
The effect of sodium ions on the electrical activity of giant axon of the squid.钠离子对鱿鱼巨大轴突电活动的影响。
J Physiol. 1949 Mar 1;108(1):37-77. doi: 10.1113/jphysiol.1949.sp004310.
2
Characterization of the electrogenic sodium pump in cardiac Purkinje fibres.心脏浦肯野纤维中电生性钠泵的特性
J Physiol. 1980 Jun;303(1):441-74. doi: 10.1113/jphysiol.1980.sp013298.
3
The effects of rubidium ions and membrane potentials on the intracellular sodium activity of sheep Purkinje fibres.铷离子和膜电位对绵羊浦肯野纤维细胞内钠活性的影响。
在离体绵羊浦肯野纤维中，毒毛花苷原导致力与细胞内钠活性之间的解离。
J Physiol. 1986 Dec;381:311-31. doi: 10.1113/jphysiol.1986.sp016329.
J Physiol. 1981 Aug;317:189-205. doi: 10.1113/jphysiol.1981.sp013820.
4
Relation between intracellular Na ion activity and tension of sheep cardiac Purkinje fibers exposed to dihydro-ouabain.暴露于二氢哇巴因的绵羊心脏浦肯野纤维细胞内钠离子活性与张力之间的关系
Biophys J. 1980 Feb;29(2):315-30. doi: 10.1016/S0006-3495(80)85135-6.
5
K+ fluctuations in the extracellular spaces of cardiac muscle. Evidence from the voltage clamp and extracellular K+ - selective microelectrodes.心肌细胞外空间的钾离子波动。来自电压钳和细胞外钾离子选择性微电极的证据。
Circ Res. 1982 Jan;50(1):1-16.
6
K efflux through inward rectifying K channels in voltage clamped Purkinje fibers.电压钳制的浦肯野纤维中通过内向整流钾通道的钾外流。
Pflugers Arch. 1980 Apr;384(3):207-17. doi: 10.1007/BF00584555.
7
Mechanism of action of therapeutic levels of cardiac glycosides.治疗剂量强心苷的作用机制。
Cardiovasc Res. 1980 Sep;14(9):495-514. doi: 10.1093/cvr/14.9.495.
8
The ouabain-sensitive fluxes of sodium and potassium in squid giant axons.乌本苷对枪乌贼巨大轴突中钠和钾通量的敏感性
J Physiol. 1969 Feb;200(2):459-96. doi: 10.1113/jphysiol.1969.sp008703.
9
Electrogenic suppression of automaticity in sheep and dog purkinje fibers.绵羊和犬浦肯野纤维自律性的电抑制
Circ Res. 1970 Sep;27(3):361-77. doi: 10.1161/01.res.27.3.361.
10
Potassium fluxes in voltage clamped Purkinje fibres.电压钳制浦肯野纤维中的钾离子通量。
Pflugers Arch Gesamte Physiol Menschen Tiere. 1966;291(1):69-84. doi: 10.1007/BF00362653.