胆囊收缩素八肽诱导豚鼠体温过高
Cholecystokinin-octapeptide-induced hyperthermia in guinea-pigs.
作者信息
Kandasamy S B, Williams B A
出版信息
Experientia. 1983 Nov 15;39(11):1282-4. doi: 10.1007/BF01990371.
PMID:6315476
Abstract
Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) at room temperature (21 degrees C) induced dose-related hyperthermia in guinea-pigs and also produced hyperthermia at low (10 degrees C) and high (30 degrees C) ambient temperatures. CCK-8-induced hyperthermia was direct and not mediated by prostaglandins, norepinephrine, cyclic AMP or naloxone-sensitive receptors.
摘要
在室温（21摄氏度）下向豚鼠脑室内注射八肽胆囊收缩素（CCK - 8）可诱导剂量相关的体温升高，并且在低（10摄氏度）和高（30摄氏度）环境温度下也会产生体温升高。CCK - 8诱导的体温升高是直接的，并非由前列腺素、去甲肾上腺素、环磷酸腺苷或纳洛酮敏感受体介导。
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