中枢注射（D-丙氨酸2，N-甲基苯丙氨酸4，甲硫氨酸（O）5-醇）-脑啡肽（FK 33-824）对家兔和豚鼠的热效应。
Hyperthermic effects of centrally injected (D-ala2, N-Me-Phe4, Met-(O)5-ol)-enkephalin (FK 33-824) in rabbits and guinea-pigs.
作者信息
Kandasamy S B, Williams B A
出版信息
Neuropharmacology. 1983 Oct;22(10):1177-81. doi: 10.1016/0028-3908(83)90077-1.
Intracerebroventricular administration of (D-ala2, N-Me-Phe4, Met-(O)5-ol)-enkephalin (FK 33-824) induced dose-related hyperthermia in rabbits and guinea-pigs. Prostaglandins (PG) and norepinephrine (NE) were not involved in the hyperthermia induced by FK 33-824 because a cyclooxygenase inhibitor, indomethacin, and an alpha-adrenoceptor antagonist, phenoxybenzamine, had no antagonistic effects. Likewise, cAMP was not required since a phosphodiesterase inhibitor, theophylline, did not accentuate the hyperthermia due to FK 33-824. It is suggested that mu receptors were involved in the induction of hyperthermia by FK 33-824 in rabbits and guinea-pigs since naloxone attenuated it. These results indicate that FK 33-824-induced hyperthermia is not mediated by PG, NE and cAMP, but rather that mu receptors are involved in the induction of hyperthermia by FK 33-824.
脑室内注射（D-ala2，N-Me-Phe4，Met-(O)5-ol）-脑啡肽（FK 33-824）可在兔和豚鼠中诱导出剂量相关的体温过高。前列腺素（PG）和去甲肾上腺素（NE）不参与FK 33-824诱导的体温过高，因为环氧化酶抑制剂吲哚美辛和α-肾上腺素能受体拮抗剂酚苄明没有拮抗作用。同样，cAMP也不是必需的，因为磷酸二酯酶抑制剂茶碱不会增强FK 33-824引起的体温过高。由于纳洛酮可减弱其作用，提示μ受体参与了兔和豚鼠中FK 33-824诱导的体温过高。这些结果表明，FK 33-824诱导的体温过高不是由PG、NE和cAMP介导的，而是μ受体参与了FK 33-824诱导的体温过高。
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