德国北莱茵 - 威斯特法伦州人类磷酸乙醇酸磷酸酶的多态性及其在亲子鉴定中的应用。

Polymorphism of the human phosphoglycolate phosphatase in Northrhine-Westphalia (F.R.G.) and its application to paternity testing.

作者信息

Henke J, Basler M, Baur M P

出版信息

Forensic Sci Int. 1983 Aug-Sep;22(2-3):137-42. doi: 10.1016/0379-0738(83)90006-3.

Abstract

Blood samples from 563 unrelated German and from 110 Turkish individuals living in the Düsseldorf area were studied for phosphoglycolate phosphatase polymorphism. The distribution of the observed phenotypes in the population genetic study did not diverge from the expected values according to Hardy-Weinberg law. In our series, the gene frequencies were calculated as follows: (a) Germans: PGP1 = 0.851, PGP2 = 0.118, PGP3 = 0.031, (b) Turks: PGP1 = 0.973, PGP2 = 0.018, PGP3 = 0.009. The assumed autosomal codominant mode of inheritance was confirmed by the examination of 109 mother-child pairs and by analysis of 70 cases of disputed paternity. The plausibility to exclude German non-fathers from paternity is 12.78%.

摘要

对来自563名居住在杜塞尔多夫地区的无血缘关系的德国人和110名土耳其人的血样进行了磷酸乙醇酸磷酸酶多态性研究。在群体遗传学研究中观察到的表型分布与根据哈迪-温伯格定律预期的值没有差异。在我们的系列研究中，基因频率计算如下：(a) 德国人：PGP1 = 0.851，PGP2 = 0.118，PGP3 = 0.031；(b) 土耳其人：PGP1 = 0.973，PGP2 = 0.018，PGP3 = 0.009。通过对109对母婴进行检查以及对70例有争议的亲子鉴定案例进行分析，证实了假定的常染色体共显性遗传模式。排除德国非亲生父亲的亲子关系的可信度为12.78%。