Jones L A, Edwards C L, Freedman R S, Tan M T, Gallager H S
Int J Cancer. 1983 Nov 15;32(5):567-71. doi: 10.1002/ijc.2910320508.
Only 69% (42 of 61) of the documented ovarian tumor specimens received between September 1981 and August 1982 contained 75% or more viable tumor. Of the 42 measured for estrogen receptors (ER) and progesterone receptors (PR), 34 (81%) had estrogen-binding titers. greater than or equal to I fmol/mg of cytosol protein, while 18 (43%) had progesterone-binding titers greater than or equal to 5 fmol/mg of cytosol protein. ER and PR titers were found to be independent of histologic grade, clinical stage, patient age, age at first pregnancy, age at menarche, age at menopause and number of pregnancies. The presence of ER and PR in malignant ovarian tumors suggests that assays positive for these hormones could aid in the selection of patients suitable for hormonal therapy.
在1981年9月至1982年8月间采集的有记录的卵巢肿瘤标本中，只有69%（61个中的42个）含有75%或更多的存活肿瘤。在42个检测了雌激素受体（ER）和孕激素受体（PR）的标本中，34个（81%）的雌激素结合滴度大于或等于1 fmol/mg细胞溶质蛋白，而18个（43%）的孕激素结合滴度大于或等于5 fmol/mg细胞溶质蛋白。发现ER和PR滴度与组织学分级、临床分期、患者年龄、初孕年龄、月经初潮年龄、绝经年龄和妊娠次数无关。恶性卵巢肿瘤中ER和PR的存在表明，这些激素检测呈阳性有助于选择适合激素治疗的患者。
