Grönroos M, Kangas L, Mäenpää J, Vanharanta R, Nieminen A L, Johansson R
Br J Obstet Gynaecol. 1984 May;91(5):472-8. doi: 10.1111/j.1471-0528.1984.tb04786.x.
Oestrogen receptor (ER) and progesterone receptor (PR) content and the response in vitro to tamoxifen (T), medroxyprogesterone acetate (MPA) and to a combination of the two hormones were determined in 21 epithelial ovarian carcinomas. The response was assessed by the level of adenosinetriphosphate in the cells. ER and PR were detected in 62% and 57%, respectively, with significant variations between the different histopathological cancer types. ER and PR predicted the response in vitro in 62% of the tumours exposed to the combined hormones, and in 38% and 33% of those exposed to T and MPA, respectively. The value of steroid-receptor determinations in selecting the proper hormonal treatment in ovarian cancer is significantly reduced because of the high proportion of incorrect predictions.
在21例上皮性卵巢癌中测定了雌激素受体（ER）和孕激素受体（PR）含量以及体外对他莫昔芬（T）、醋酸甲羟孕酮（MPA）及两种激素联合应用的反应。通过细胞中三磷酸腺苷水平评估反应。ER和PR的检测率分别为62%和57%，不同组织病理学类型的癌症之间存在显著差异。在联合激素处理的肿瘤中，ER和PR预测体外反应的准确率为62%，在单独使用T和MPA处理的肿瘤中分别为38%和33%。由于错误预测比例较高，类固醇受体测定在选择卵巢癌合适激素治疗方面的价值显著降低。
