Ndiritu C G, Ouldridge E J, Head M, Rweyemamu M M
J Hyg (Lond). 1983 Oct;91(2):335-41. doi: 10.1017/s0022172400060356.
Serological evaluations of foot-and-mouth disease type SAT 2 viruses isolated in Kenya between 1979 and 1982 were performed using the two-dimensional microneutralization test. Nine field isolates of epizootiological significance were compared with four vaccine viruses. The results obtained identified Tan 5/68 as the most appropriate reference vaccine virus strain since it had the broadest serological spectrum. Potent Tan 5/68 vaccines would be expected to provide adequate protection against the contemporary SAT 2 field viruses. In the case of K183/74, which also was shown to have a broad spectrum with viruses isolated in Kenya, the results show that the 1982 isolate from central Kenya was significantly divergent (r less than 1.00 at P = 0.01) and warranted tactical revaccination for its control. The study highlighted the fact that strain R1215 which had been isolated from the oesophageal-pharyngeal swabs of asymptomatic carrier cattle had a narrow serological spectrum suggesting that such viruses could be unsuitable as vaccine for the national campaign.
利用二维微量中和试验对1979年至1982年间在肯尼亚分离出的口蹄疫SAT 2型病毒进行了血清学评估。将9株具有流行病学意义的野外分离株与4株疫苗病毒进行了比较。所得结果确定Tan 5/68为最合适的参考疫苗病毒株，因为它具有最广的血清学谱。预计高效的Tan 5/68疫苗能为抵御当代SAT 2型野外病毒提供充分保护。对于同样被证明与在肯尼亚分离出的病毒具有广谱性的K183/74，结果表明1982年从肯尼亚中部分离出的毒株有显著差异（在P = 0.01时r小于1.00），需要进行战术性再接种以控制该病毒。该研究突出了这样一个事实，即从无症状携带牛的食管 - 咽拭子中分离出的R1215毒株血清学谱较窄，这表明此类病毒可能不适用于全国性疫苗接种运动。
