鱿鱼巨大轴突中钠通道的氢离子阻断
Hydrogen ion block of the sodium pore in squid giant axons.
作者信息
Begenisich T, Danko M
出版信息
J Gen Physiol. 1983 Nov;82(5):599-618. doi: 10.1085/jgp.82.5.599.
Abstract
The block of squid axon sodium channels by H ions was studied using voltage-clamp and internal perfusion techniques. An increase in the concentration of internal permeant ions decreased the block produced by external H ions. The voltage dependence of the block was found to be nonmonotonic: it was reduced by both large positive and large negative potentials. The ability of internal ions to modify the block by external H+ is explained by a competition among these ions for a binding site within the pore. The nonmonotonic voltage dependence is consistent with this picture if the hydrogen ions are allowed to be permeant.
摘要
利用电压钳和内部灌注技术研究了氢离子对鱿鱼轴突钠通道的阻断作用。内部可渗透离子浓度的增加降低了外部氢离子产生的阻断作用。发现阻断作用的电压依赖性是非单调的：在大的正电位和大的负电位下阻断作用均减弱。内部离子改变外部氢离子阻断作用的能力可通过这些离子在孔内结合位点的竞争来解释。如果允许氢离子通透，这种非单调的电压依赖性与该情况是一致的。
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