Wang Xiaohong, Yamauchi Shinobu, Sun Jirun
American Dental Association Science & Research Institute, Gaithersburg, MD 20899, USA.
Research Center for Electron Photon Science, Tohoku University, Sendai 982-0826, Japan.
J Funct Biomater. 2022 Aug 26;13(3):128. doi: 10.3390/jfb13030128.
The objective of this study is to replace a traditional methacrylate-based primer (glycine, N-(2-hydroxy-3-(2-methyl-1-oxo-2-propenyl)propyl)-N-(4-methylphenyl) monosodium salt, NTG-GMA) with a hydrolytically stable ether-based primer (glycine, N-2-hydroxy-3-(4-vinylbenzyloxy)-propyl-N-(4-methylphenyl), monosodium salt, NTG-VBGE). The performance and durability of bonding composites to detin of two primers combined with methacrylate-based or ether-based adhesives were evaluated using shear bond strength (SBS) and micro-tensile bond strength (μTBS) combined with thermal cycling. The hydrolysis resistance of NTG-VBGE against hydrolysis was tested by challenging primed hydroxyapatite crystals with an esterase. The hydrophilicity of the primers and the resin spreading kinetics of adhesives on primed dentin were characterized by water contact angle measurements. The new primer NTG-VBGE was found to be compatible with both methacrylate-based adhesives and ether-based adhesives. The highest μTBS values were found in the test group of NTG-VBGE and ether-based adhesive, which was consistent with the resin spreading kinetics results. The more hydrophobic and hydrolytically stable primer/adhesive achieved improved dentin infiltration and bonding strength, suggesting significant potential for further developing dental restorative materials with extended service life.
本研究的目的是用一种水解稳定的醚基底漆（甘氨酸，N-2-羟基-3-(4-乙烯基苄氧基)-丙基-N-(4-甲基苯基)，单钠盐，NTG-VBGE）替代传统的甲基丙烯酸酯基底漆（甘氨酸，N-(2-羟基-3-(2-甲基-1-氧代-2-丙烯基)丙基)-N-(4-甲基苯基)，单钠盐，NTG-GMA）。使用剪切粘结强度（SBS）和微拉伸粘结强度（μTBS）并结合热循环，评估了两种底漆与甲基丙烯酸酯基或醚基粘合剂结合用于牙本质粘结复合材料的性能和耐久性。通过用酯酶挑战涂有底漆的羟基磷灰石晶体来测试NTG-VBGE的抗水解性。通过测量水接触角来表征底漆的亲水性以及粘合剂在涂有底漆的牙本质上的树脂铺展动力学。发现新型底漆NTG-VBGE与甲基丙烯酸酯基粘合剂和醚基粘合剂均兼容。在NTG-VBGE和醚基粘合剂的测试组中发现了最高的μTBS值，这与树脂铺展动力学结果一致。疏水性更强且水解稳定的底漆/粘合剂实现了更好的牙本质渗透和粘结强度，这表明在进一步开发具有更长使用寿命的牙科修复材料方面具有巨大潜力。
