Crabbe J C, Keith L D, Kosobud A, Stack J
Life Sci. 1983 Nov 7;33(19):1877-87. doi: 10.1016/0024-3205(83)90672-0.
Resting pituitary levels of beta-endorphin-(beta-EP-IR), ACTH-(ACTH-IR), and alpha-MSH-(alpha-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependence led to reduced pituitary beta-EP-IR in 4 of 5 strains studied. After 24 hr of withdrawal, 3 of those 4 showed elevated pituitary beta-EP-IR. These results are consistent with the hypothesis that genetically-determined difference in pituitary hormone functioning underlie some of the genetically-determined differences in ethanol withdrawal severity.
研究发现，16种近交系小鼠垂体中β-内啡肽（β-EP-IR）、促肾上腺皮质激素（ACTH-IR）和α-促黑素（α-MSH-IR）样免疫反应物质的基础水平存在差异。激素水平与乙醇戒断的严重程度存在遗传相关性，不同品系之间的乙醇戒断严重程度也有所不同。在所研究的5个品系中，有4个品系的乙醇依赖导致垂体β-EP-IR降低。戒断24小时后，这4个品系中有3个品系的垂体β-EP-IR升高。这些结果与以下假设一致：垂体激素功能的遗传决定差异是乙醇戒断严重程度的一些遗传决定差异的基础。
