Zagon I S, McLaughlin P J
Life Sci. 1983 Dec 12;33(24):2449-54. doi: 10.1016/0024-3205(83)90639-2.
Naltrexone, a potent opiate antagonist, had both stimulatory and inhibitory effects on somatic growth in preweaning rats depending on dose. Daily injections of 50 mg/kg naltrexone, which blocked morphine-induced analgesia for 24 hr/day, resulted in increased body and organ weights, and acceleration in the appearance of physical characteristics and maturation of spontaneous motor activity. Naltrexone in a dosage of 1 mg/kg, which blocked morphine-induced analgesia for 4 hr/day, had the opposite effects. These results show that naltrexone can modulate growth, and suggest a role for the endorphins and opiate receptors in developmental events.
纳曲酮是一种强效阿片类拮抗剂，根据剂量不同，对断奶前大鼠的躯体生长有刺激和抑制两种作用。每日注射50毫克/千克纳曲酮，可阻断吗啡诱导的镇痛作用达每天24小时，结果导致体重和器官重量增加，身体特征出现加速以及自发运动活动成熟加快。剂量为1毫克/千克的纳曲酮，可阻断吗啡诱导的镇痛作用达每天4小时，其作用则相反。这些结果表明纳曲酮可以调节生长，并提示内啡肽和阿片受体在发育过程中发挥作用。
