Zagon I S, McLaughlin P J
Science. 1983 Aug 12;221(4611):671-3. doi: 10.1126/science.6867737.
Naltrexone, an opiate antagonist, had both stimulatory and inhibitory effects, depending on the dosage, on the growth of S20Y neuroblastoma in A/Jax mice. Daily injections of 0.1 milligram of naltrexone per kilogram of body weight, which blocked morphine-induced analgesia for 4 to 6 hours per day, resulted in a 33 percent tumor incidence, a 98 percent delay in the time before tumor appearance, and a 36 percent increase in survival time. Neuroblastoma-inoculated mice receiving 10 milligrams of naltrexone per kilogram, which blocked morphine-induced analgesia for 24 hours per day, had a 100 percent tumor incidence, a 27 percent reduction in the time before tumor appearance, and a 19 percent decrease in survival time. Inoculation of neuroblastoma cells in control subjects resulted in 100 percent tumor incidence within 29 days. These results show that naltrexone can modulate tumor response and suggest a role for the endorphin-opiate receptor system in neuro-oncogenic events.
纳曲酮是一种阿片类拮抗剂，根据剂量不同，对A/Jax小鼠体内S20Y神经母细胞瘤的生长具有刺激和抑制两种作用。每天每千克体重注射0.1毫克纳曲酮，该剂量每天可阻断吗啡诱导的镇痛作用4至6小时，结果导致肿瘤发生率为33%，肿瘤出现前的时间延迟98%，存活时间增加36%。接种神经母细胞瘤的小鼠每千克体重接受10毫克纳曲酮，该剂量每天可阻断吗啡诱导的镇痛作用24小时，其肿瘤发生率为100%，肿瘤出现前的时间减少27%，存活时间减少19%。在对照实验对象中接种神经母细胞瘤细胞，29天内肿瘤发生率达100%。这些结果表明，纳曲酮可以调节肿瘤反应，并提示内啡肽-阿片受体系统在神经肿瘤发生事件中发挥作用。
