Brueton M J, Berger H M, Brown G A, Ablitt L, Iyngkaran N, Wharton B A
Gut. 1978 Feb;19(2):95-8. doi: 10.1136/gut.19.2.95.
Patterns of glycine and taurine conjugation of bile acids in duodenal juice have been studied in 20 low birth weight babies at 12 and 22 days of age. They were fed from birth on one of three feeds containing different amounts of taurine and its precursors, cysteine and methionone. Taurine conjugation predominated in those fed on human milk throughout the first three weeks of life. In those fed on SMA or S26 infant feeding formulae, both of which contain very little taurine, concentrations of glycine conjugates were found to exceed those of taurine conjugates by the 12th day. The low glycine-taurine conjugate ratios previously described in newborn babies are, therefore, probably related to the taurine content of the milk which they received. Glycine-taurine conjugate ratios less than 1.0 occur in breast fed infants during the first three weeks of life.
对20名低体重出生婴儿在12日龄和22日龄时十二指肠液中胆汁酸的甘氨酸和牛磺酸结合模式进行了研究。这些婴儿从出生起就采用三种不同的喂养方式之一，这三种喂养方式的奶液中含有不同量的牛磺酸及其前体半胱氨酸和蛋氨酸。在生命的前三周，以母乳为食的婴儿中牛磺酸结合占主导。在以SMA或S26婴儿配方奶粉为食的婴儿中，这两种配方奶粉中牛磺酸含量都很少，到第12天时发现甘氨酸结合物的浓度超过了牛磺酸结合物的浓度。因此，先前描述的新生儿中较低的甘氨酸 - 牛磺酸结合物比例可能与他们所摄入奶液中的牛磺酸含量有关。母乳喂养的婴儿在生命的前三周中甘氨酸 - 牛磺酸结合物比例小于1.0。
