Clarke A, File S E
Psychoneuroendocrinology. 1983;8(3):343-50. doi: 10.1016/0306-4530(83)90009-4.
The time spent in active social interaction by pairs of male rats in a dimly-lit, familiar test arena, was decreased significantly after intraseptal injection of ACTH4-10 (250-500 ng). In contrast, the time spent in active social interaction was increased significantly after intraseptal injection of the tri-substituted ACTH4-9 analogue ORG 2766 (250-500 pg). Neither ACTH4-10 (250 ng) nor ORG 2766 (250 pg) affected exploration or locomotor activity measured in a holeboard, after intraseptal injection. Intraseptally administered ACTH4-10 (250 ng) increased aggression measured in a colony intruder model, but ORG 2766 (250 pg) was without effect.
在光线昏暗、熟悉的测试场地中，对雄性大鼠进行隔区内注射促肾上腺皮质激素4 - 10（250 - 500纳克）后，其主动社交互动的时间显著减少。相比之下，隔区内注射三取代促肾上腺皮质激素4 - 9类似物ORG 2766（250 - 500皮克）后，主动社交互动的时间显著增加。隔区内注射后，促肾上腺皮质激素4 - 10（250纳克）和ORG 2766（250皮克）均未影响在洞板实验中测量的探索或运动活动。隔区内注射促肾上腺皮质激素4 - 10（250纳克）会增加在群体入侵者模型中测量的攻击性，但ORG 2766（250皮克）则无此作用。
