Cefis F, Cattaneo M, Carnevale Ricci P M, Frigerio B, Usellini L, Capella C
Ultrastruct Pathol. 1983 Jul;5(1):45-53. doi: 10.3109/01913128309141818.
A case of primary malignant laryngeal carcinoid with dual endocrine and mucous differentiation is reported. Histologically the tumor showed a characteristic organoid pattern and exhibited Alcian-blue, periodic acid-Schiff, and Grimelius silver positivity. By the immunoperoxidase technique calcitonin, ACTH, and alpha-hCG subunit were demonstrated in the tumor cells. Electron microscopy revealed two different types of endocrinelike cells: mucous cells and occasional cells containing both endocrinelike granules and mucin droplets. Diagnostic morphologic criteria of this rare tumor entity are discussed and reference to biologic behavior and possible histogenesis is made.
报告了一例具有双内分泌和黏液分化的原发性喉恶性类癌病例。组织学上，肿瘤呈现特征性的器官样结构，对阿尔辛蓝、过碘酸希夫染色及吉姆萨银染色呈阳性。通过免疫过氧化物酶技术，在肿瘤细胞中证实了降钙素、促肾上腺皮质激素及α-人绒毛膜促性腺激素亚基的存在。电子显微镜显示出两种不同类型的内分泌样细胞：黏液细胞以及偶尔同时含有内分泌样颗粒和黏液滴的细胞。讨论了这种罕见肿瘤实体的诊断形态学标准，并提及了生物学行为及可能的组织发生。
