Kolarov J, Nelson B D, Kuzela S
Biochem Biophys Res Commun. 1983 Oct 31;116(2):383-7. doi: 10.1016/0006-291x(83)90533-8.
Rat liver protoporphyrinogen IX oxidase is not formed in mitochondria in contrast to the claims made for the yeast enzyme (Poulson and Polglase, FEBS Lett. (1974) 40, 258). Inhibition of mitochondrial protein synthesis in regenerating rat livers by thiamphenicol led, instead, to a slight increase in protoporphyrinogen oxidase activity. Protoporphyrinogen IX oxidase was not induced in rat liver by triiodothyronine, an inducer of mitochondrial protein synthesis, or by AIA, an inducer of heme synthesis. Significant increases in activity were observed to be associated with rapidly growing cells, such as regenerating livers and rat ascites hepatoma cells.
与针对酵母酶的说法（Poulson和Polglase，《欧洲生物化学学会联合会快报》（1974年）40卷，258页）相反，大鼠肝脏原卟啉原IX氧化酶并非在线粒体中形成。相反，甲砜霉素对再生大鼠肝脏中线粒体蛋白质合成的抑制导致原卟啉原氧化酶活性略有增加。三碘甲状腺原氨酸（一种线粒体蛋白质合成诱导剂）或AIA（一种血红素合成诱导剂）均未在大鼠肝脏中诱导出原卟啉原IX氧化酶。观察到活性的显著增加与快速生长的细胞有关，例如再生肝脏和大鼠腹水肝癌细胞。
