Werner A, Hayat H, Har-Kedar Y, Brenner H J
Br J Radiol. 1983 Dec;56(672):945-8. doi: 10.1259/0007-1285-56-672-945.
Between the years 1974 and the beginning of 1977, 199 patients with stage II infiltrating duct carcinoma of the breast were treated with post-operative radiation, using a 250 kVp X-ray machine. Three treatment schedules were used consisting of 22, 26.2 and 29.6 Gy (2200, 2620 and 2960 rad) total tumour dose, calculated at 2 cm depth, with 5, 3 and 3 fractions a week respectively. The frequency of local recurrences, mainly in the chest wall, were 20.3%, 8.3% and 8.1% respectively. The latter two frequencies were not different from those reported for the commonly used high dose treatments of 45-60 Gy (4500-6000 rad) delivered either as given doses or tumour doses. An approximate 70% five year survival rate was similar in the three groups and does not differ from results observed with high doses. Low dose treatment is advantageous, because it has fewer complications and it can be delivered in a smaller number of sessions, making it more convenient to the patient, without loss of efficacy. The results presented of the low dose treatment may reflect the existence of an optimal dose level of radiation.
在1974年至1977年初期间，199例II期乳腺浸润性导管癌患者接受了术后放疗，使用的是一台250 kVp的X射线机。采用了三种治疗方案，总肿瘤剂量分别为22、26.2和29.6 Gy（2200、2620和2960 rad），在2 cm深度处计算得出，每周分别为5、3和3次分割。局部复发的频率主要在胸壁，分别为20.3%、8.3%和8.1%。后两个频率与报道的常用高剂量治疗（45 - 60 Gy，4500 - 6000 rad，以给定剂量或肿瘤剂量给予）的频率没有差异。三组的五年生存率约为70%，与高剂量治疗的结果相似。低剂量治疗具有优势，因为它并发症较少，且可以在较少的疗程内完成，对患者更方便，同时不损失疗效。低剂量治疗的结果可能反映了存在一个最佳辐射剂量水平。
