Gelmers H J
Clin Neurol Neurosurg. 1983;85(4):213-24. doi: 10.1016/0303-8467(83)90071-9.
Calcium is an important intracellular 'second messenger' in the activation of contractile proteins in vascular smooth muscle cells. Intracellular calcium accumulation probably has a major pathological effect in the occurrence of ischemic cell damage. Calcium antagonists are a heterogenous group of substances with one property in common, that is they interfere with the transmembrane movement of calcium. Their therapeutic usefulness in cerebral vasospasms, migraine and cerebral ischemia is reviewed.
钙是血管平滑肌细胞中收缩蛋白激活过程中重要的细胞内“第二信使”。细胞内钙蓄积在缺血性细胞损伤的发生中可能具有主要病理作用。钙拮抗剂是一类具有共同特性的异质性物质，即它们干扰钙的跨膜转运。本文综述了它们在脑血管痉挛、偏头痛和脑缺血中的治疗作用。
