长期阿片类药物治疗不会改变大鼠大脑皮层、肾脏以及神经肿瘤细胞系NCB20中的α2 - 肾上腺素能受体。
Chronic opiate treatment does not modify alpha 2-adrenergic receptors in rat cerebral cortex, kidney and in the neurotumor cell line NCB20.
作者信息
Vicentini L M, Miller R J, Robertson M J
出版信息
Eur J Pharmacol. 1983 Nov 25;95(3-4):265-70. doi: 10.1016/0014-2999(83)90644-1.
We examined the effect of chronic opiate treatment on the alpha 2-adrenergic receptor binding of both the agonist [3H]clonidine and the antagonist [3H]yohimbine in the cerebral cortex and kidney of rats. In addition, we demonstrated the presence of an adrenergic receptor of the alpha 2 type on the neurotumor cell line NCB20 and used this cell line as a model for studying the interaction between the opiate and alpha 2-adrenergic systems. In all the three above systems, chronic opiate treatment did not modify the number or the affinity of alpha 2-adrenergic receptors.
我们研究了长期阿片类药物治疗对大鼠大脑皮层和肾脏中激动剂[³H]可乐定和拮抗剂[³H]育亨宾的α₂-肾上腺素能受体结合的影响。此外，我们证明了神经肿瘤细胞系NCB20上存在α₂型肾上腺素能受体，并将该细胞系用作研究阿片类药物与α₂-肾上腺素能系统之间相互作用的模型。在上述所有三个系统中，长期阿片类药物治疗均未改变α₂-肾上腺素能受体的数量或亲和力。
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