Garcia-Sevilla J A, Ugedo L, Ulibarri I, Gutierrez M
Psychopharmacology (Berl). 1986;88(4):489-92. doi: 10.1007/BF00178512.
The density of platelet alpha 2-adrenoceptors, quantified by means of the binding of [3H]clonidine, and the aggregation response induced by adrenaline, was investigated in ten heroin addicts. The number of binding sites for [3H]clonidine was significantly increased during heroin abuse. Concomitantly, there was a potentiation of the adrenaline-induced platelet aggregation, which suggested that continuous heroin use (opiate dependence) is associated with supersensitive platelet alpha 2-adrenoceptors in human addicts. Spontaneous heroin withdrawal further increased in the same addicts the density of platelet alpha 2-adrenoceptors. These results suggest that platelet alpha 2-adrenoceptors may be used as a model to study receptor mechanisms of opiate dependence and withdrawal in humans.
通过[3H]可乐定结合来定量血小板α2 -肾上腺素能受体的密度，并研究了10名海洛因成瘾者中肾上腺素诱导的聚集反应。在海洛因滥用期间，[3H]可乐定的结合位点数量显著增加。同时，肾上腺素诱导的血小板聚集增强，这表明持续使用海洛因（阿片类药物依赖）与人类成瘾者血小板α2 -肾上腺素能受体超敏有关。在同一批成瘾者中，海洛因自然戒断进一步增加了血小板α2 -肾上腺素能受体的密度。这些结果表明，血小板α2 -肾上腺素能受体可作为研究人类阿片类药物依赖和戒断受体机制的模型。
