Helmeste D M
Eur J Pharmacol. 1983 Nov 25;95(3-4):277-81. doi: 10.1016/0014-2999(83)90646-5.
Low doses of d-amphetamine (1.0 mg/kg) can reduce the spontaneous hyperactivity of BALB/cJ mice. Amphetamine-induced hypolocomotion can be antagonized by NCA and sulpiride pretreatment, suggesting that this is a dopaminergic phenomenon. However, behaviorally active doses of NCA do not alter brain D2 dopamine receptor binding in either mice or rats. NCA also did not induce stereotypy/catalepsy or affect apomorphine-induced stereotypy. The results suggest that another type of dopamine receptor may mediate the behavioral effects of amphetamine and NCA.
低剂量的右旋苯丙胺（1.0毫克/千克）可降低BALB/cJ小鼠的自发性多动。NCA和舒必利预处理可拮抗苯丙胺诱导的运动减少，这表明这是一种多巴胺能现象。然而，行为活性剂量的NCA并不会改变小鼠或大鼠脑中D2多巴胺受体的结合。NCA也不会诱发刻板症/僵住症，或影响阿扑吗啡诱导的刻板行为。结果表明，另一种类型的多巴胺受体可能介导苯丙胺和NCA的行为效应。
