哌唑嗪给药后突触前α2-肾上腺素能受体的解离：哌唑嗪的突触前效应。
Dissociation of presynaptic alpha 2-adrenoceptors following prazosin administration: presynaptic effect of prazosin.
作者信息
Vizi E S, Ludvig N, Rónai A Z, Folly G
出版信息
Eur J Pharmacol. 1983 Nov 25;95(3-4):287-90. doi: 10.1016/0014-2999(83)90648-9.
PMID:6317415
Abstract
Evidence has been obtained that prazosin possesses a presynaptic alpha 2-adrenoceptor blocking action in the rat was deferens preparation stimulated at 1 Hz. In the presence of prazosin yohimbine failed to affect the presynaptic alpha 2-adrenoceptor stimulatory effect of 1-noradrenaline while the effect of xylazine was almost completely abolished. It is therefore suggested that there are two kinetically different prejunctional alpha 2-adrenoceptor sites.
摘要
已获得证据表明，在以1赫兹频率刺激的大鼠输精管标本中，哌唑嗪具有突触前α2肾上腺素能受体阻断作用。在哌唑嗪存在的情况下，育亨宾未能影响1-去甲肾上腺素的突触前α2肾上腺素能受体刺激作用，而赛拉嗪的作用几乎完全被消除。因此，提示存在两种动力学不同的突触前α2肾上腺素能受体位点。
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