用脑心肌炎（EMC）病毒或聚肌苷酸-聚胞苷酸（poly(I)poly(C)）诱导荷瘤小鼠体内2',5'-寡聚腺苷酸合成酶。
Induction of 2',5' oligo(A) synthetase in tumor-bearing mice with encephalomyocarditis (EMC) virus or poly(I)poly(C).
作者信息
Galaktidou G, Kortsaris A, Koliais S I
出版信息
FEBS Lett. 1983 Nov 28;164(1):161-5. doi: 10.1016/0014-5793(83)80041-6.
PMID:6317439
Abstract
Infection of 13 month-old C3H mice with EMC virus or inoculation with the interferon inducer poly(I)poly(C) results in elevated levels of the enzyme 2',5' oligo(A) synthetase only in animals with spontaneous tumors (breast cancer or hepatomas). High enzymatic activities are detected in homogenates from liver, spleen, plasma and neoplastic cells of the animals with breast carcinomas and only in the neoplastic liver cells of the animals with hepatomas.
摘要
用EMC病毒感染13月龄的C3H小鼠或接种干扰素诱导剂聚肌苷酸-聚胞苷酸（poly(I)poly(C)），结果显示只有在患有自发性肿瘤（乳腺癌或肝癌）的动物中，2',5'-寡聚腺苷酸合成酶的水平才会升高。在患有乳腺癌的动物的肝脏、脾脏、血浆和肿瘤细胞的匀浆中检测到高酶活性，而在患有肝癌的动物中，仅在肿瘤性肝细胞中检测到高酶活性。
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