Flici O, Tadjerouni A, Robyn C
J Gynecol Obstet Biol Reprod (Paris). 1983;12(6):579-82.
Gestational trophoblastic tumours group together the complete hydatidiform mole (classical) and partial mole (with fetus), invasive mole and choriocarcinoma. Genetically, trophoblastic tumours can arise in different ways: they can derive from normal zygotes with the maternal and paternal haplotype (normal pregnancy), or from a triploid zygote (partial mole) or from an XX zygote possessing only a duplicated male haplotype and no maternal contribution (complete mole). The low malignancy rate in partial mole (2.4%) compared to the complete mole (10 to 20%) remains unknown. Further analysis of the genetics of these tumours may well contribute to the understanding of the process of carcinogenesis.
妊娠滋养细胞肿瘤包括完全性葡萄胎（经典型）、部分性葡萄胎（伴有胎儿）、侵蚀性葡萄胎和绒毛膜癌。从遗传学角度来看，滋养细胞肿瘤可以通过不同方式发生：它们可以源自具有母方和父方单倍型的正常合子（正常妊娠），或者源自三倍体合子（部分性葡萄胎），或者源自仅具有重复男性单倍型且无母方成分的XX合子（完全性葡萄胎）。与完全性葡萄胎（10%至20%）相比，部分性葡萄胎的低恶性率（2.4%）仍不清楚。对这些肿瘤的遗传学进行进一步分析很可能有助于理解致癌过程。
