Hadar T, Tovi F, Sidi J, Sarov B, Sarov I
J Med Virol. 1983;12(4):237-45. doi: 10.1002/jmv.1890120403.
The role of herpes simplex virus (HSV) and varicella zoster virus (VZV) in acute peripheral facial palsy (APFP) was evaluated in 153 patients. The sera of patients were examined for IgG and IgA antibodies to HSV and VZV by the immunoperoxidase antibody-membrane antigen (IPAMA) technique. The prevalence of IgG and IgA seropositivity to HSV was significantly higher in the APFP patients than in the matched control group. No significant difference was found in the geometric mean titer (GMT) to HSV antibodies in the APFP patients compared to the matched control groups. The prevalence of IgA antibodies to VZV was significantly higher in the APFP patients group than in the matched control group. The GMT for VZV IgG antibodies was significantly higher in the APFP patients than in the matched control group. No significant difference was found in the GMT of VZV IgA antibodies. Eleven of 83 patients for whom paired sera were available had significantly increased or decreased IgG and IgA antibody titers to VZV on subsequent examination. Four of these patients did not show any evidence of zosterian eruption. These studies support the concept that VZV and HSV might have a role in the etiopathogenesis of APFP in some of the patients.
对153例患者评估了单纯疱疹病毒（HSV）和水痘带状疱疹病毒（VZV）在急性周围性面瘫（APFP）中的作用。采用免疫过氧化物酶抗体-膜抗原（IPAMA）技术检测患者血清中针对HSV和VZV的IgG和IgA抗体。APFP患者中HSV IgG和IgA血清阳性率显著高于匹配的对照组。与匹配的对照组相比，APFP患者中HSV抗体的几何平均滴度（GMT）无显著差异。APFP患者组中VZV IgA抗体的阳性率显著高于匹配的对照组。APFP患者中VZV IgG抗体的GMT显著高于匹配的对照组。VZV IgA抗体的GMT无显著差异。在83例有配对血清的患者中，11例在随后的检查中VZV的IgG和IgA抗体滴度显著升高或降低。其中4例患者未出现任何带状疱疹皮疹的证据。这些研究支持这样一种观点，即VZV和HSV可能在部分APFP患者的发病机制中起作用。
