School of Medical Sciences - Santa Casa de São Paulo, Brazil.
Braz J Otorhinolaryngol. 2010 May-Jun;76(3):370-3. doi: 10.1590/S1808-86942010000300016.
Although Bell's palsy is the major cause of acute peripheral facial palsy, its pathogenesis remains unknown. Reactivation of the varicella zoster virus has been implicated as one of the main causes of Bell's palsy, however, studies which investigate the varicella zoster virus reactivation in Bell's palsy patients are mostly Japanese and, therefore, personal and geographic characteristics are quite different from our population.
To determine varicella zoster virus frequency in saliva samples from patients with Bell's palsy, using PCR.
One hundred seventy one patients with acute peripheral facial palsy were prospectively enrolled in this study. One hundred twenty were clinically diagnosed with Bell's palsy, within one week of onset of the disease and no previous anti-viral therapy. We had 20 healthy adults as controls. Three saliva samples were collected from patients and controls at initial examination and at one and two weeks later. The detection of the varicella zoster virus DNA was performed using PCR.
Varicella zoster virus was detected in two patients (1.7%). The virus was not identified in saliva samples from the controls.
Varicella zoster virus was detected in 1.7% of saliva samples from patients with Bell's palsy, using PCR.
使用 PCR 技术检测疱疹病毒在贝尔氏麻痹症患者唾液样本中的频率。
本研究前瞻性纳入了 171 例急性周围性面瘫患者。其中 120 例在发病 1 周内且未接受抗病毒治疗时，经临床诊断为贝尔氏麻痹症，20 例健康成年人作为对照组。患者和对照组在初次检查时及 1 周和 2 周后分别采集 3 份唾液样本。采用 PCR 法检测疱疹病毒 DNA。
PCR 检测到 2 例（1.7%）患者的唾液样本中存在疱疹病毒。对照组的唾液样本中未检测到疱疹病毒。
PCR 法检测到 1.7%的贝尔氏麻痹症患者的唾液样本中存在疱疹病毒。
