Weissenbacher M C, Sabattini M S, Avila M M, Sangiorgio P M, de Sensi M R, Contigiani M S, Levis S C, Maiztegui J I
J Med Virol. 1983;12(4):273-80. doi: 10.1002/jmv.1890120407.
To determine the prevalence of inapparent infection with Junin virus among the rural population and its relation to the clinical disease, a serological study was carried out in two zones of the endemic area of Argentine hemorrhagic fever (AHF). From the first appearance of AHF in the zones (1963) and the moment of the survey (1977), 14 years had passed. A total of 695 serum samples were obtained, 540 from Córdoba and 155 from Buenos Aires. Of the 695 serum samples, 83 were positive for neutralizing antibodies against Junin virus. Total infection (clinical and inapparent cases) reached 11.6% and 12.03% in the Buenos Aires and Córdoba zones, respectively, showing that the total prevalence of infection in two zones separated by 320 miles, are very much alike. In Córdoba province, the prevalence of clinical infection was 7.59%, while that for inapparent infection was 4.44%. Values for the Province of Buenos Aires were 9.67% and 1.93%, respectively. In addition to a low prevalence of inapparent infections, the results of this survey show that roughly 90% of the population is susceptible to contract the disease; this stresses the need to immunize susceptible individuals in the endemic area.
为确定阿根廷出血热（AHF）流行区农村人口中胡宁病毒隐性感染的流行情况及其与临床疾病的关系，在阿根廷出血热流行区的两个地区开展了一项血清学研究。从这些地区首次出现阿根廷出血热（1963年）到进行调查时（1977年），已经过去了14年。共采集了695份血清样本，其中540份来自科尔多瓦，155份来自布宜诺斯艾利斯。在这695份血清样本中，83份针对胡宁病毒的中和抗体呈阳性。布宜诺斯艾利斯和科尔多瓦地区的总感染率（临床病例和隐性感染病例）分别达到11.6%和12.03%，这表明相隔320英里的两个地区的总感染流行率非常相似。在科尔多瓦省，临床感染率为7.59%，隐性感染率为4.44%。布宜诺斯艾利斯省的相应数值分别为9.67%和1.93%。除隐性感染流行率较低外，本次调查结果还显示，大约90%的人口易感染该疾病；这凸显了对流行区易感个体进行免疫接种的必要性。
