Payer A F, Parkening T A
J Ultrastruct Res. 1983 Sep;84(3):317-25. doi: 10.1016/s0022-5320(83)80011-2.
Membrane-bound intranuclear inclusions have been described, for the first time, in the Leydig cell of the Chinese hamster (Cricetulus griseus). The inclusions were not found in the 1-day-old animal, rarely found prior to sexual maturity, and commonly found in the sexually mature animals. The incidence of inclusions increases with aging. Their size and content varies greatly. They are surrounded by a single membrane and completely enclosed by nucleoplasm. Their close association with nuclear invaginations of cytoplasmic material, and their content of cytoplasmic structures along with some exhibiting the presence of trimetaphosphatase reaction product, suggest a cytoplasmic origin. This phenomenon involves the migration of cytoplasmic structures into the nucleus followed by detachment on the nucleoplasmic side. The presence of the inclusions is not an indication of an abnormality of the Leydig cell. The Leydig cell of the Chinese hamster may be an excellent model to study factors that initiate inclusion formation, and to determine the functional role of membrane-bound intranuclear inclusions.
首次在中国仓鼠（黑线仓鼠）的睾丸间质细胞中描述了膜结合核内包涵体。在1日龄的动物中未发现包涵体，在性成熟前很少发现，而在性成熟动物中普遍存在。包涵体的发生率随年龄增长而增加。它们的大小和内容物差异很大。它们被单层膜包围，并完全被核质包围。它们与细胞质物质的核内陷紧密相关，并且它们的细胞质结构内容物以及一些显示出三偏磷酸酶反应产物的存在，表明其起源于细胞质。这种现象涉及细胞质结构迁移到细胞核中，随后在核质一侧分离。包涵体的存在并不表明睾丸间质细胞异常。中国仓鼠的睾丸间质细胞可能是研究引发包涵体形成的因素以及确定膜结合核内包涵体功能作用的极佳模型。
