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人类衰老睾丸中莱迪希细胞的超微结构

Ultrastructure of Leydig cells in human ageing testes.

作者信息

Paniagua R, Amat P, Nistal M, Martin A

机构信息

Department of Cytology and Histology, Faculty of Biology, University of Salamanca, Spain.

出版信息

J Anat. 1986 Jun;146:173-83.

PMID:3693056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166533/
Abstract

Ultrastructural study of Leydig cells in elderly men revealed the following Leydig cell types: (1) ultrastructurally normal Leydig cells (46.2%); (2) Leydig cells either with multiple cytoplasmic or intranuclear Reinke crystals or with numerous para-crystalline inclusions (6.1%); (3) multivacuolated Leydig cells with the cytoplasm almost filled by lipid droplets (16.7%; (4) dedifferentiated Leydig cells with poor development of agranular endoplasmic reticulum and mitochondria, and increased amounts of lipofuscin granules (22.3%); and (5) bi- or trinucleate Leydig cells (8.7%) showing either a normal (2.8%) or dedifferentiated (5.9%) cytoplasm. These results suggest an involution of Leydig cells with advancing age. A correlation between the proportion of altered Leydig cells and the decrease in testosterone and increase in luteinising hormone levels could be observed.

摘要

对老年男性睾丸间质细胞的超微结构研究揭示了以下几种睾丸间质细胞类型

(1) 超微结构正常的睾丸间质细胞 (46.2%)；(2) 具有多个细胞质或核内雷氏结晶或大量类晶体包涵体的睾丸间质细胞 (6.1%)；(3) 多泡性睾丸间质细胞，其细胞质几乎被脂滴充满 (16.7%)；(4) 去分化的睾丸间质细胞，其无颗粒内质网和线粒体发育不良，脂褐素颗粒数量增加 (22.3%)；以及 (5) 双核或三核睾丸间质细胞 (8.7%)，其细胞质表现为正常 (2.8%) 或去分化 (5.9%)。这些结果表明，随着年龄的增长，睾丸间质细胞会发生退化。可以观察到改变的睾丸间质细胞比例与睾酮水平降低和黄体生成素水平升高之间存在相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/c066b2a854f9/janat00187-0181-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/c67dde986b41/janat00187-0180-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/c066b2a854f9/janat00187-0181-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/939563fec7c1/janat00187-0177-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/2b45222fd15f/janat00187-0177-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/7649aad00fa0/janat00187-0178-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/0f221b7720a2/janat00187-0178-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/5b485c53ebb9/janat00187-0178-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/9042c2c99ed3/janat00187-0179-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/10f96153f686/janat00187-0180-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/c67dde986b41/janat00187-0180-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/8c21725fc3c6/janat00187-0180-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/b183c6dffb43/janat00187-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/4350db6a3185/janat00187-0181-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf2/1166533/c066b2a854f9/janat00187-0181-c.jpg

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本文引用的文献

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Leydig cell function and morphology in the rat testis after exposure to heat.热暴露后大鼠睾丸中睾丸间质细胞的功能和形态
Andrologia. 1980 Jan-Feb;12(1):12-9. doi: 10.1111/j.1439-0272.1980.tb00568.x.
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Semen characteristics as a function of age in 833 fertile men.833名可育男性精液特征与年龄的关系
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Ultrastructural classification of paracrystalline inclusions in untreated and estrogen treated human Leydig cells.未经处理和经雌激素处理的人睾丸间质细胞中副晶状内含物的超微结构分类
Anat Rec. 1980 Oct;198(2):175-82. doi: 10.1002/ar.1091980205.
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Leydig cell types in primary testicular disorders.原发性睾丸疾病中的睾丸间质细胞类型。
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