亚硝化雷尼替丁在大鼠肝细胞原代培养物中诱导的非程序性DNA合成。
Unscheduled DNA synthesis induced by nitrosated ranitidine in primary cultures of rat hepatocytes.
作者信息
Martelli A, Fugassa E, Voci A, Brambilla G
出版信息
Mutat Res. 1983 Dec;122(3-4):373-6. doi: 10.1016/0165-7992(83)90022-2.
PMID:6318101
Abstract
In vitro, the reaction, in acidified solution, of the histamine H2 receptor antagonist ranitidine with excess nitrite, yielded nitroso derivative(s) eliciting a dose-dependent amount of unscheduled DNA synthesis in primary cultures of rat hepatocytes.
摘要
在体外，组胺H2受体拮抗剂雷尼替丁在酸化溶液中与过量亚硝酸盐反应，生成亚硝基衍生物，该衍生物在大鼠肝细胞原代培养物中引发剂量依赖性的非预定DNA合成。
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