Vignon F, Capony F, Garcia M, Veith F, Westley B, Rochefort H
Ann Endocrinol (Paris). 1981 Oct-Nov;42(4-5):327-32.
The hormone dependence and the prognosis of human breast cancers are currently based on assays of the estrogen receptor (RE) and progesterone receptor (RP) in the tumor. However, such prediction can not be fully accurate: RE may be non functional in some tumors and the estrogenic regulation of RP is not directly correlated with the effects of estrogens on cell growth. Here we described other estrogen induced intracellular, secreted or membrane proteins. Investigations of these proteins should allow a better understanding of the mechanisms by which estrogens stimulate the growth and spreading of breast cancer. Some secreted proteins could even be useful as circulatory markers of hormone dependence.
目前，人类乳腺癌的激素依赖性及预后是基于对肿瘤中雌激素受体（RE）和孕激素受体（RP）的检测。然而，这种预测并非完全准确：RE在某些肿瘤中可能无功能，且RP的雌激素调节与雌激素对细胞生长的影响并无直接关联。在此，我们描述了其他雌激素诱导的细胞内、分泌型或膜蛋白。对这些蛋白的研究应能更好地理解雌激素刺激乳腺癌生长和扩散的机制。一些分泌蛋白甚至可用作激素依赖性的循环标志物。
