Ogden D C, Colquhoun D
Pflugers Arch. 1983 Nov;399(3):246-8. doi: 10.1007/BF00656725.
The efficacy of acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction was estimated by single channel recording. The probability of channel opening at high concentration was found to be greater than 0.9 for each, thus showing (a) that their efficacy is high and (b) that the opening rate for the fully-liganded channel is higher than previously thought.
通过单通道记录评估了乙酰胆碱、卡巴胆碱和辛二酰胆碱在青蛙神经肌肉接头处的效能。发现每种药物在高浓度时通道开放的概率均大于0.9，因此表明：（a）它们的效能很高；（b）完全被配体占据的通道的开放速率比之前认为的要高。
