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大脑中神经降压素与多巴胺的相互作用:综述

Interactions between neurotensin and dopamine in the brain: an overview.

作者信息

Quirion R

出版信息

Peptides. 1983 Sep-Oct;4(5):609-15. doi: 10.1016/0196-9781(83)90005-0.

DOI:10.1016/0196-9781(83)90005-0
PMID:6318198
Abstract

Neurotensin (NT)-like immunoreactivity is found in high concentrations in many brain areas under important dopaminergic control, such as the nucleus accumbens and the substantia nigra and its receptors are also highly concentrated in the A-9 and A-10 regions. Neurotensin-induced behavioral actions after intracerebral injections bear many similarities with neuroleptics. Moreover, NT is able to modify dopamine metabolism in various brain regions. Finally, 6-hydroxydopamine (6-OHDA) lesions of A-9 and A-10 regions markedly decrease NT receptors in these areas and in the caudate-putamen. All together, these data strongly suggest that NT interacts with mesolimbic and nigrostriatal dopaminergic pathways in the brain.

摘要

在许多受重要多巴胺能控制的脑区,如伏隔核、黑质,可发现高浓度的神经降压素(NT)样免疫反应性,其受体也高度集中在A-9和A-10区域。脑内注射后神经降压素诱导的行为作用与抗精神病药物有许多相似之处。此外,NT能够改变不同脑区的多巴胺代谢。最后,A-9和A-10区域的6-羟基多巴胺(6-OHDA)损伤显著降低了这些区域以及尾状核-壳核中的NT受体。总之,这些数据有力地表明,NT与脑中的中脑边缘和黑质纹状体多巴胺能通路相互作用。

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