Petrov N M, Petrova N S
Probl Endokrinol (Mosk). 1983 Nov-Dec;29(6):23-7.
Clinical and physiological data, characterizing a total endocrinological status, thyroid hormone secretion and the cardiovascular functional state, were determined in 68 patients with diffuse toxic goiter of different severity. Lithium carbonate tablets (0.3 g) were indicated orally in a dose of 0.9 to 1.2 g daily during 3--4 months. Good results were obtained in 48.5% of the patients, moderate ones in 41.2% and in 10.3% of cases the drug was ineffective. Over a period of lithium carbonate treatment the thyroid iodine-containing and hormone-forming functions improved, renin plasmatic activity and cortisol level lowered, hyperactivity of the insular apparatus diminished. Hemocirculatory signs returned to normal and hyperdynamic ones decreased. Lithium carbonate is particularly effective in mild and moderate thyrotoxicoses, as well as during a preparing patients for the radical treatment, i.e. strumectomy.
对68例不同严重程度的弥漫性毒性甲状腺肿患者测定了表征全内分泌状态、甲状腺激素分泌及心血管功能状态的临床和生理数据。口服碳酸锂片（0.3g），剂量为每日0.9至1.2g，持续3至4个月。48.5%的患者取得了良好效果，41.2%的患者效果中等，10.3%的病例药物无效。在碳酸锂治疗期间，甲状腺含碘及激素生成功能改善，肾素血浆活性和皮质醇水平降低，胰岛器官的功能亢进减轻。血液循环体征恢复正常，高动力体征减少。碳酸锂在轻度和中度甲状腺毒症中特别有效，以及在为患者进行根治性治疗（即甲状腺切除术）做准备期间也有效。
