Brando B, Civati G, Grillo C, Busnach G, Colussi G, Broggi M L, Minetti L
Proc Eur Dial Transplant Assoc. 1983;20:265-70.
Twelve viral episodes occurred in 54 antilymphocyte globulin-treated renal transplant recipients (two primary cytomegalovirus, seven cytomegalovirus reactivations, one chickenpox, two influenza). In 11 of 12 cases the ratio between peripheral T4 and T8 subsets fell (from 1.698 to 0.986, p less than 0.01) due both to a reduction of T4+ and to an increase of T8+ cells. T10+ and 5/9 subsets also increased. Suppressor T-cell function, as measured by two simultaneous assays, was enhanced. In antibody-negative CMV patients the reversal of T4/T8 ratio preceded the appearance of specific IgM. T4/T8 ratios rapidly returned to normal in mild episodes, but remained reverted in symptomatic CMV patients for several months, despite a reduction in the immunosuppressive regimen. Symptomatic viral episodes displayed marked imbalances in T cell subset numbers and function, while in asymptomatic cases the changes were less evident.
54例接受抗淋巴细胞球蛋白治疗的肾移植受者发生了12次病毒感染事件（2例原发性巨细胞病毒感染、7例巨细胞病毒再激活、1例水痘、2例流感）。在12例中的11例中，外周血T4和T8亚群的比例下降（从1.698降至0.986，p<0.01），这是由于T4+细胞减少和T8+细胞增加所致。T10+和5/9亚群也增加。通过两种同步检测方法测量的抑制性T细胞功能增强。在抗体阴性的巨细胞病毒患者中，T4/T8比例的逆转先于特异性IgM的出现。在轻度感染事件中，T4/T8比例迅速恢复正常，但在有症状的巨细胞病毒患者中，尽管免疫抑制方案有所减少，但仍持续数月处于逆转状态。有症状的病毒感染事件显示T细胞亚群数量和功能存在明显失衡，而在无症状病例中，变化则不太明显。
