Tsutsui K, Sakata T, Oomura Y, Arase K, Fukushima M, Hinohara Y
Physiol Behav. 1983 Oct;31(4):493-502. doi: 10.1016/0031-9384(83)90072-0.
1,5-Anhydroglucitol (1-DG) has been known as an antimetabolic glucose analogue. Using gas chromatography, 1-DG was found to be physiologically present in rat serum. In order to investigate its direct and long-term effects on feeding, 1-DG was infused during the light period into the rat third ventricle in doses of 3.0, 6.0 and 12.0 mumol/rat. Its effects were then compared to those of similarly applied 2-deoxy-D-glucose (2-DG). Following initial hyperphagia, both of these glucose-analogues produced suppressive effects on feeding during the subsequent day throughout the light and dark periods. On the third day after 2-DG injection reduction of feeding did not recover completely to the pretreatment baseline levels, but it did recover after 1-DG. Both 1-DG and 2-DG caused linear dose-related hypophagia, with the slope for 1-DG being about half of that for 2-DG. It is suggested that the delayed hypophagia which followed the initial hyperphagia produced by deoxyglucose was a result of sustained inactivation of the Na-pump due to intracellular ATP deficiency caused by accumulation of deoxy-glucose-6-phosphate.
1,5-脱水葡萄糖醇（1-DG）一直被认为是一种抗代谢葡萄糖类似物。通过气相色谱法发现，1-DG在大鼠血清中呈生理性存在。为了研究其对进食的直接和长期影响，在光照期间将1-DG以3.0、6.0和12.0 μmol/大鼠的剂量注入大鼠第三脑室。然后将其效果与同样应用的2-脱氧-D-葡萄糖（2-DG）的效果进行比较。在最初的摄食亢进之后，这两种葡萄糖类似物在随后一天的整个光照和黑暗期间均对进食产生抑制作用。在注射2-DG后的第三天，进食减少并未完全恢复到预处理基线水平，但在注射1-DG后恢复了。1-DG和2-DG均引起与剂量相关的线性摄食减少，1-DG的斜率约为2-DG的一半。有人提出，脱氧葡萄糖引起的最初摄食亢进之后出现的延迟性摄食减少是由于脱氧葡萄糖-6-磷酸积累导致细胞内ATP缺乏，从而使钠泵持续失活的结果。
