Engeset R M, Ritter R C
Brain Res. 1980 Nov 24;202(1):229-33.
Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more food than they did 6 h after control infusions. These data indicate that activation of brain glucoreceptors may mediate increased feeding even after other signs of cerebral glucoprivation have disappeared.
脑室内（ICV）注入2-脱氧-D-葡萄糖（2-DG）会引发高血糖，并在短时间内增加进食量。如果在注入2-DG后6小时内阻止大鼠获取食物，此时血糖水平正常且脑内2-DG浓度几乎为零，这些大鼠的进食量仍显著高于对照注入后6小时的进食量。这些数据表明，即使在脑内葡萄糖缺乏的其他迹象消失后，脑葡萄糖感受器的激活仍可能介导进食量增加。
