Intracerebroventricular 2-DG causes feeding in the absence of other signs of glucoprivation.

Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more food than they did 6 h after control infusions. These data indicate that activation of brain glucoreceptors may mediate increased feeding even after other signs of cerebral glucoprivation have disappeared.