Naharro G, Robbins K C, Reddy E P
Science. 1984 Jan 6;223(4631):63-6. doi: 10.1126/science.6318314.
The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70gag-fgr is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.
已确定加德纳-拉希德猫肉瘤病毒（GR-FeSV）编码其主要翻译产物p70gag-fgr的区域的核苷酸序列。根据该核苷酸序列推导了这种转化蛋白的氨基酸序列。计算机分析表明，P70gag-fgr的一部分与肌动蛋白（一种真核细胞骨架蛋白）具有广泛的氨基酸序列同源性。P70gag-fgr的第二个区域与酪氨酸特异性激酶基因家族密切相关。因此，v-fgr癌基因似乎是由涉及两个不同细胞基因的重组事件产生的，一个编码结构蛋白，另一个编码蛋白激酶。
