猫逆转录病毒致癌基因（v-fes）的核苷酸序列为酪氨酸特异性蛋白激酶基因家族提供了证据。

Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes.

作者信息

Hampe A, Laprevotte I, Galibert F, Fedele L A, Sherr C J

出版信息

Cell. 1982 Oct;30(3):775-85. doi: 10.1016/0092-8674(82)90282-3.

Abstract

The nucleotide sequences encoding the transforming polyproteins of the Snyder-Theilen and Gardner-Arnstein strains of feline sarcoma virus (FeSV) have been determined. These sequences include a viral transforming gene (v-fes), derived from cellular proto-oncogene sequences (c-fes) of domestic cats by recombination with feline leukemia virus (FeLV). The v-fes sequences are predicted to encode a polypeptide domain strikingly similar to that specified by the transforming gene (v-fps) of the avian Fujinami sarcoma virus. In addition, the 3' 0.8 kilobase pairs of v-fes encode amino acid sequences homologous to the carboxy-terminal portion of pp60src, the transforming protein encoded by the avian Rous sarcoma virus src gene. Thus different feline and avian retroviral transforming genes, all of which encode functionally related proteins with associated tyrosine-specific kinase activities, must be derived from divergent members of the same proto-oncogene family.

摘要

已经确定了猫肉瘤病毒（FeSV）的斯奈德 - 泰伦（Snyder-Theilen）和加德纳 - 阿恩斯坦（Gardner-Arnstein）毒株编码转化多聚蛋白的核苷酸序列。这些序列包括一个病毒转化基因（v-fes），它是通过与猫白血病病毒（FeLV）重组，从家猫的细胞原癌基因序列（c-fes）衍生而来的。预计v-fes序列编码的多肽结构域与禽富氏肉瘤病毒的转化基因（v-fps）所指定的结构域惊人地相似。此外，v-fes的3'端0.8千碱基对编码与禽劳氏肉瘤病毒src基因编码的转化蛋白pp60src的羧基末端部分同源的氨基酸序列。因此，不同的猫和禽逆转录病毒转化基因，所有这些基因都编码具有相关酪氨酸特异性激酶活性的功能相关蛋白，必定源自同一原癌基因家族的不同成员。