Pawlotsky Y, Louboutin J Y, Chales G, Flouvat B, Roux A
Sem Hop. 1983 Dec 12;59(46):3218-20.
Eighteen patients with chronic inflammatory joint disease were treated for two successive five day sequences, in a double blind crossover study, with 300 mg per day ketoprofen given alone or combined with 1,500 mg aspirin. Bioavailability and pharmacokinetics of total serum ketoprofen studied in eight patients did not appear to be significantly modified by addition of aspirin. Measurements of Ritchie's articular index and Lee's functional index demonstrated that ketoprofen was clinically as effective when given alone as in association with aspirin. Measurement of the sedimentation rate by the sigma ESR technique showed that aspirin produced a marked reduction of the antiinflammatory biological activity of ketoprofen which did not however reach statistical significance. This study of interactions between ketoprofen and aspirin shows that it is useless and perhaps harmful to combine the two medications.
在一项双盲交叉研究中，18例慢性炎症性关节病患者连续接受两个为期五天的治疗疗程，每天单独给予300毫克酮洛芬或与1500毫克阿司匹林联合使用。对8例患者研究发现，加用阿司匹林似乎并未显著改变血清总酮洛芬的生物利用度和药代动力学。Ritchie关节指数和Lee功能指数测量结果表明，酮洛芬单独使用时在临床上与联合阿司匹林时同样有效。采用西格玛血沉率（sigma ESR）技术测量血沉率显示，阿司匹林使酮洛芬的抗炎生物活性显著降低，但未达到统计学意义。这项关于酮洛芬与阿司匹林相互作用的研究表明，将这两种药物联合使用既无益处，甚至可能有害。
