Pawlotsky Y, Durand B, Delbary A, Le Treut A, Catheline M, Bourel M
Nouv Presse Med. 1977 Jan 29;6(4):255-8.
Two groups, A and B, were selected at random amongst a total of 31 patients suffering from chronic inflammatory rheumatic disorders. The patients in group A (n = 16) received succesively: Placebo (2d), Indomethacin (5d). Indomethacin + aspirin (5d). The order of the 5 day treatment periods was reversed for the patients in group b (n = 15). The daily dose of indomethacin was 150 mg. That of aspirin was 1500 mg. Four parameters were measured at the end of each period of treatment: total serum indomethacin, articular index (Ritchie), ESR (Westergren) and the sigma ESR - a new technique for the measurement of sedimentation rate. No conclusions could be drawn from the analysis of variations in ESR. Concordant and statistically significnat variations in articular index and the sigma ESR showed a reduction in the activity of indomethacin under the influence of aspirin. The inhibitory effect of aspirin. The inhibitory effect of aspirin continues after the drug stopped. This reduction in indomethacin activity is not related to a decrease in serum concentrations of the medication which are not significantly altered when aspirin is taken.
从31名患有慢性炎症性风湿性疾病的患者中随机选取了A、B两组。A组（n = 16）患者依次接受：安慰剂（2天）、吲哚美辛（5天）、吲哚美辛 + 阿司匹林（5天）。B组（n = 15）患者5天治疗期的顺序则相反。吲哚美辛的日剂量为150毫克，阿司匹林的日剂量为1500毫克。在每个治疗期结束时测量四个参数：血清总吲哚美辛、关节指数（里奇）、血沉（魏氏法）和西格玛血沉——一种测量血沉率的新技术。血沉变化分析未得出结论。关节指数和西格玛血沉的一致且具有统计学意义的变化表明，在阿司匹林的影响下，吲哚美辛的活性降低。阿司匹林的抑制作用。药物停用后，阿司匹林的抑制作用仍持续。吲哚美辛活性的这种降低与药物血清浓度的降低无关，服用阿司匹林时血清浓度没有显著变化。
