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[双氯芬酸在风湿病临床实践中的应用]

[Bi-Profenid in rheumatologic practice].

作者信息

Mazières B, Harrewyn J M, Arlet J

出版信息

Sem Hop. 1983 Dec 12;59(46):3235-9.

PMID:6318349
Abstract

Sixty-six patients managed in an outpatient clinic for various inflammatory or degenerative conditions were given 300 mg per day of Bi-Profenid in two daily doses of one 150 mg tablet each, for 20 days. At completion of the trial, patients with degenerative disease showed a statistically significant improvement in pain upon mobilization, nocturnal pain and pain index as evaluated by the pain scale. Similarly, in patients with inflammatory conditions, significant effectiveness was recorded upon nocturnal pain, overall pain as assessed by the pain scale and articular index. Tolerance was considered satisfactory in more than 65% of cases. The most common undesirable side-effect was gastric pain (22.7%). Bi-Profenid thus confirms its effectiveness in pain due to arthrosis as well as in inflammatory conditions.

摘要

在门诊诊所接受治疗的66例患有各种炎症或退行性疾病的患者,每天服用300毫克必洛芬(Bi-Profenid),分两次服用,每次150毫克片剂,持续20天。试验结束时,退行性疾病患者在活动时的疼痛、夜间疼痛以及通过疼痛量表评估的疼痛指数方面,均显示出具有统计学意义的改善。同样,在炎症性疾病患者中,夜间疼痛、通过疼痛量表评估的总体疼痛以及关节指数方面均记录到显著疗效。超过65%的病例耐受性良好。最常见的不良副作用是胃痛(22.7%)。因此,必洛芬证实了其在骨关节炎疼痛以及炎症性疾病中的有效性。

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