Camus J P, Fournie A, Ayrolles C, Koeger A C, Prier A
Sem Hop. 1983 Dec 12;59(46):3221-4.
The effectiveness of Bi-Profenid tablets and Profenid capsules was studied comparatively in patients with inflammatory joint disease. 43 patients with rheumatoid arthritis or various chronic inflammatory joint diseases were given 300 mg of Bi-Profenid in 2 daily oral doses and 300 mg of Profenid in 3 daily oral doses, for two consecutive 7 day periods. This double blind cross-over study was carried out in two rheumatology centers. Effectiveness of the two forms of ketoprofen on morning stiffness and pain scale was found to be comparable. However, patients more often preferred Bi-Profenid (15 cases) to Profenid (10 cases); 12 patients reported no difference. Tolerance was excellent in 92.7% of cases under Profenid capsules and in 94.8% of cases under Bi-Profenid tablets.
对患有炎性关节疾病的患者，比较了双氯芬酸片和酮洛芬胶囊的疗效。43例类风湿性关节炎或各种慢性炎性关节疾病患者，连续两个7天期间，每日分2次口服给予300mg双氯芬酸，每日分3次口服给予300mg酮洛芬。这项双盲交叉研究在两个风湿病中心进行。发现两种酮洛芬剂型对晨僵和疼痛量表的疗效相当。然而，与酮洛芬（10例）相比，更多患者（15例）更喜欢双氯芬酸；12例患者表示无差异。服用酮洛芬胶囊的患者中92.7%耐受性良好，服用双氯芬酸片的患者中94.8%耐受性良好。
