Kit S, Trkula D, Qavi H, Dreesman G, Kennedy R C, Adler-Storthz K, Kaufman R, Adam E
Sex Transm Dis. 1983 Apr-Jun;10(2):67-71. doi: 10.1097/00007435-198304000-00004.
Virus isolated from a woman presenting with the first symptomatic episode of genital herpes was identified as herpes simplex virus type 1 (HSV-1) by restriction nuclease fingerprinting. Testing for IgM antibody to HSV indicated that the patient had recently contracted a new HSV infection. Virus microneutralization and the micro-solid phase radioimmunometric test for IgG, however, showed that the patient had had prior infection with herpes simplex virus type 2 (HSV-2); thus the HSV-1 infection was acquired despite the presence of antibody to HSV-2. Genital herpes recurred about four, seven, and nine months after the HSV-1 infection. Isolates from the latter three episodes all were of an identical strain of HSV-2 and were not recombinants or a mixture of the viruses. The data show that two distinctly different herpes simplex viruses can initiate genital infections in one individual and suggest that HSV-2 is more likely to recur than HSV-1.
从一名首次出现生殖器疱疹症状的女性身上分离出的病毒，经限制性核酸酶指纹图谱鉴定为1型单纯疱疹病毒（HSV-1）。对HSV的IgM抗体检测表明，该患者最近感染了一种新的HSV。然而，病毒微量中和试验以及针对IgG的微固相放射免疫测定显示，该患者先前感染过2型单纯疱疹病毒（HSV-2）；因此，尽管存在HSV-2抗体，该患者仍感染了HSV-1。生殖器疱疹在HSV-1感染后约4个月、7个月和9个月复发。后三次发作分离出的病毒均为同一株HSV-2，并非重组体或病毒混合物。数据表明，两种截然不同的单纯疱疹病毒可在同一个体引发生殖器感染，提示HSV-2比HSV-1更易复发。
